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Volume 1 No. 2
15 December 2015
The century of neuroscience

Akira Teramoto, Huancong Zuo, Yuqi Zhang, Tatsuya Kondo

2015, 1(2): 73-74.   doi:10.18679/CN11-6030/R.2015.017
Abstract ( 348 )    PDF(1665KB) ( 492 ) HTML ()   Save
Differentiated cells derived from fetal neural stem cells improve motor deficits in a rat model of Parkinson's disease

Wei Wang, Hao Song, Aifang Shen, Chao Chen, Yanming Liu, Yabing Dong, Fabin Han

2015, 1(2): 75-85.   doi:10.18679/CN11-6030/R.2015.009
Abstract ( 700 )    PDF(39299KB) ( 1700 ) HTML ()   Save
Objective: Parkinson's disease (PD), which is one of the most common neurodegenerative disorders, is characterized by the loss of dopamine (DA) neurons in the substantia nigra in the midbrain. Experimental and clinical studies have shown that fetal neural stem cells (NSCs) have therapeutic effects in neurological disorders. The aim of this study was to examine whether cells that were differentiated from NSCs had therapeutic effects in a rat model of PD. Methods:...
Morphological predictors of posterior communicating artery aneurysms rupture

Nan Lv, Yibin Fang, Ying Yu, Jinyu Xu, Jianmin Liu, Qinghai Huang

2015, 1(2): 86-91.   doi:10.18679/CN11-6030/R.2015.010
Abstract ( 554 )    PDF(5696KB) ( 777 ) HTML ()   Save
Objective: The conflicting findings of previous morphological studies on intracranial aneurysm rupture may be caused by the different locations of aneurysms. We aimed to determine the independent risk factors of aneurysm rupture by focusing on only posterior communicating artery (PcomA) aneurysms. Methods: In 89 PcomA aneurysms (58 ruptured, 31 unruptured), clinical and morphological characteristics were compared between the ruptured and unruptured groups. Multi...
Rare bilateral C3 cervical spondylolysis:Report of four cases and a literature review

Huaiyu Tong, Hongzhen Jiang, Xinguang Yu, Yuanzheng Zhang

2015, 1(2): 92-96.   doi:10.18679/CN11-6030/R.2015.011
Abstract ( 397 )    PDF(14296KB) ( 201 ) HTML ()   Save
Objective: To review and discuss the etiology, diagnosis and treatment C3 of bilateral cervical spondylolysis. Methods: This was a retrospective review of the clinical features, imaginge findings, and treatment of 4 cases of bilateral C3 cervical spondylolysis, with a review of the literature. Results: A 21-year-old woman, a 26-year-old man, a 14-year-old boy, and a 46-year-old man were diagnosed with bilateral C3 cervical spondylolysis. The pat...
Progress in the research and development of nerve conduits

Xiyuan Wang, Lin Chen, Qiang Ao, Aruna Sharma, Hari Shanker Sharma

2015, 1(2): 97-101.   doi:10.18679/CN11-6030/R.2015.012
Abstract ( 570 )    PDF(3557KB) ( 981 ) HTML ()   Save
The reconstruction after peripheral nerve damage, especially for long-segment nerve defects, remains a clinical challenge. Autologous nerve graft transplantation is an efficient method for the repair of peripheral nerve defects, but the involved complications and shortcomings have greatly limited the clinical efficacy of treatments offered to patients with nerve defects. Thus, there is an urgent need to develop new therapeutic strategies and explore alternatives to autologous nerve transplantati...
Why does a little mean a lot when you have nothing? A brief review of cell therapy strategies for spinal cord injury

Dajue Wang

2015, 1(2): 102-109.   doi:10.18679/CN11-6030/R.2015.013
Abstract ( 736 )    PDF(9419KB) ( 314 ) HTML ()   Save
Without an understanding of functional musculoskeletal system recovery, the translation of knowledge concerning neurological recovery from laboratory discoveries to bedside applications will be incomplete. Because improvements in neurological function after cell transplantation are minor and can be easily ignored, this article draws attention to the minimal improvements required to allow a spinal cord injury patient or person to live a relatively independent life. These minimal improvements incl...
Regulations and ethical codes for clinical cell therapy trials in Iran

Hooshang Saberi, Nazi Derakhshanrad, Babak Arjmand, Jafar Ai, Masoud Soleymani, Amir Ali Hamidieh, Mohammad Taghi Joghataei, Zahid Hussain Khan, Seyed Hassan Emami Razavi

2015, 1(2): 110-113.   doi:10.18679/CN11-6030/R.2015.014
Abstract ( 603 )    PDF(1689KB) ( 1056 ) HTML ()   Save
Objective: The local regulations for conducting experimental and clinical cell therapy studies are dependent on the national and cultural approach to the issue, and may have many common aspects as well as differences with the regulations in other countries. The study reflects the latest national aspects of cell therapy in Iran and relevant regulations. Methods: The following topics are discussed in the article including sources of cell harvest, regulations for c...
Regulations in the United States for cell transplantation clinical trials in neurological diseases

He Zhu, Yuanqing Tan, Qi Gu, Weifang Han, Zhongwen Li, Jason S. Meyer, Baoyang Hu

2015, 1(2): 114-124.   doi:10.18679/CN11-6030/R.2015.015
Abstract ( 576 )    PDF(3667KB) ( 900 ) HTML ()   Save
Objective: This study aimed to use a systematic approach to evaluate the current utilization, safety, and effectiveness of cell therapies for neurological diseases in human. And review the present regulations, considering United States (US) as a representative country, for cell transplantation in neurological disease and discuss the challenges facing the field of neurology in the coming decades. Methods: A detailed search was performed in systematic literature r...
Stem cell transplantation for nervous system disorders in Italy, European Union, and Ukraine: Clinical approach and governmental policies

Dario Siniscalco, Nataliia Sych

2015, 1(2): 125-127.   doi:10.18679/CN11-6030/R.2015.016
Abstract ( 536 )    PDF(1702KB) ( 543 ) HTML ()   Save
Several debates have been raised over the use of stem cells in the field of regenerative medicine. Indeed, stem cell transplantation must follow strict rules. However, to date, many differences exist among different Western and Eastern European countries. This brief review summarizes the state-of-the-art stem cell regulation in Italy, European Union, and Ukraine.
Special section on new neuroimaging and clinical research

2015, 1(2): 128-128.  
Abstract ( 218 )    PDF(134KB) ( 264 ) HTML ()   Save
Index

2015, 1(2): 129-130.  
Abstract ( 184 )    PDF(141KB) ( 245 ) HTML ()   Save
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