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Volume 2 No. 1
31 March 2016
Biomarkers in Alzheimer's disease

Rajka M. Liscic, Yuanhan Yang

2016, 2(1): 1-2.   doi:10.18679/CN11-6030/R.2016.002
Abstract ( 502 )    PDF(1633KB) ( 582 ) HTML ()   Save
Alzheimer's disease (AD) so far did not have promising treatment. The accurate and early diagnosis is still the important issue. For these purpose, biomarkers related to diagnosis, clinical course, and other aims have been proposed and reported. Meanwhile, along with the ongoing researches for AD, biomarkers with their own aims are also on the way.
Effects of aging on working memory performance and prefrontal cortex activity: A time-resolved spectroscopy study

Jie Shi, Wenjing Zhou, Tongchao Geng, Huancong Zuo, Masahiro Tanida, Kaoru Sakatani

2016, 2(1): 3-7.   doi:10.18679/CN11-6030/R.2016.006
Abstract ( 381 )    PDF(3122KB) ( 625 ) HTML ()   Save
Objective: This study aimed to employ time-resolved spectroscopy (TRS) to explore age-related differences in prefrontal cortex (PFC) activity while subjects performed a working memory task. Methods: We employed TRS to measure PFC activity in ten healthy younger and ten healthy older subjects while they performed a working memory (WM) task. All subjects performed the Sternberg test (ST) in which the memory-set size varied between one and six digits. Using TRS, we...
An association between the location of white matter changes and the behavioral and psychological symptoms of dementia in Alzheimer's disease patients

Tzuchou Lin, Yihui Lin, Linli Kao, Yihui Kao, Yuanhan Yang, Pingsong Chou, Mengni Wu

2016, 2(1): 8-16.   doi:10.18679/CN11-6030/R.2016.010
Abstract ( 519 )    PDF(1725KB) ( 884 ) HTML ()   Save
Objective: The frontal lobe may be involved in circuits associated with depression, apathy, aggression, and other psychiatric symptoms. Although white matter changes (WMC) are related to the severity of behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer's disease (AD), it is unclear which part of the WMC may play the most important role in BPSD. This study was designed to investigate the relationship between the location of WMC and the severity o...
Effects of regional cerebral blood flow perfusion on learning and memory function and its molecular mechanism in rats

Cunli Xu, Wenhua Wu, Lingbin Kong

2016, 2(1): 17-24.   doi:10.18679/CN11-6030/R.2016.009
Abstract ( 542 )    PDF(1047KB) ( 673 ) HTML ()   Save
Objective: To study the effects of regional cerebral blood flow (rCBF) perfusion on learning and memory function in special brain areas and its molecular mechanism in rat. Methods: Sixty-four adult male healthy Sprague-Dawley (SD) rats were randomly divided into two groups: A false operation group and an operation group. The false operation group was randomly divided into four subgroups (A0, B0, C0, and D0) and the ope...
Malignant transformation and treatment of cystic mixed germ cell tumor

Yapeng Zhao, Hongyu Duan, Qinghui Zhang, Bingxin Shi, Hui Liang, Yuqi Zhang

2016, 2(1): 25-30.   doi:10.18679/CN11-6030/R.2016.001
Abstract ( 691 )    PDF(4495KB) ( 687 ) HTML ()   Save
Objective: The authors report an extremely unusual presentation and management of a children pineal mixed germ cell tumor mainly composed of immature teratoma, aiming to summarize main theraptic points by literature review. Methods: A cystic lesion located in the rear of third ventricle in a child was detected 3 years ago with no other therapy performed except for a ventriculo-peritoneal shunt. During the following 3 years, intermitted regular brain MRI demonstr...
Repairing skull defects in children with nano-hap/collagen composites: A clinical report of thirteen cases

Tuoyu Chen, Yuqi Zhang, Huancong Zuo, Yapeng Zhao, Chaoqiang Xue, Bin Luo, Qinglin Zhang, Jin Zhu, Xiumei Wang, Fuzhai Cui

2016, 2(1): 31-37.   doi:10.18679/CN11-6030/R.2016.005
Abstract ( 645 )    PDF(3915KB) ( 869 ) HTML ()   Save
Objective: To evaluate the clinical results of repairing skull defects with biomimetic bone (nano-hap/collagen composites, NHACs) in children. Methods: Thirteen children with skull defects were treated with NHACs in our hospital. The NHACs molded with the help of a 3D printer were used in the operations. Results: All 13 operations were successful, and patients recovered without infection. Only one patient suffered from subcutaneous hydrops post-...
Dementia in Taiwan area

Yuanhan Yang

2016, 2(1): 38-45.   doi:10.18679/CN11-6030/R.2016.011
Abstract ( 570 )    PDF(1743KB) ( 1547 ) HTML ()   Save
Objective: Taiwan has an increasing aging population like other developed areas. The aging population will lead to an increased prevalence of dementia. Methods: This article will reflect the status of dementia in Taiwan, including updated epidemiology, diagnosis, subtypes, and optimal treatment of dementia. Results: The article also describes and interprets the Taiwan Dementia Policy to establish a clear, large view of the current state of manag...
Effects of the APOE ε4 allele on therapeutic response in Alzheimer's disease

I Chien, Yuanhan Yang

2016, 2(1): 46-49.   doi:10.18679/CN11-6030/R.2016.012
Abstract ( 477 )    PDF(1689KB) ( 645 ) HTML ()   Save
The apolipoprotein E (APOE) ε4 allelle is a well-established risk factor for cognitive decline. Racial factors may mitigate its effects. However, APOE ε4 has similar effects even among different racial groups. The APOE genotype in patients with Alzheimer's disease may influence therapeutic decisions.
Cell-based therapy in Alzheimer's disease: Current knowledge and perspective

Liyan Qiao, Hongyun Huang, Lin Chen

2016, 2(1): 50-58.   doi:10.18679/CN11-6030/R.2016.007
Abstract ( 546 )    PDF(1730KB) ( 721 ) HTML ()   Save
Alzheimer's disease (AD) is the most prevalent type of dementia, and its neuropathology is characterized by the deposition of insoluble β-amyloid (Aβ) peptides, intracellular neurofibrillary tangles, amyloid angiopathy, age-related brain atrophy, synaptic pathology, white matter rarefaction, granulovacuolar degeneration, neuron loss, and neuroinflammation. Although much is known about the neurobiology of AD, very few conventional therapies are available to arrest or slow the disease. T...
Surgical complications secondary to decompressive craniectomy for patients with severe head trauma

Xiaofeng Yang, Liang Wen

2016, 2(1): 59-64.   doi:10.18679/CN11-6030/R.2016.008
Abstract ( 567 )    PDF(1569KB) ( 1114 ) HTML ()   Save
Decompressive craniectomy (DC) is a surgical method for managing highly elevated intracranial increased pressure (ICP) resulted from severe head trauma. This procedure is able to reduce the ICP rapidly and effectively. However, it may lead to kinds of secondary complications, which would cause patient's severe neurological dysfunction or even death. In this paper, we reviewed the literatures about surgical complications secondary to DC, and tried to bring up suggestions on surgical techniques ai...
Looking for positive viewpoints for Alzheimer's caregivers: Case evaluation of a positive energy group

Wenchien Hsieh, Qinying Chen, Qingling Sun, Peixuan Chen, Yijia Chen, Wenting Xu, Yiting Zhang, Yiqian Yu, Yimei Huang

2016, 2(1): 65-70.   doi:10.18679/CN11-6030/R.2016.003
Abstract ( 480 )    PDF(1690KB) ( 574 ) HTML ()   Save
Objective: As estimated in a report of global Alzheimer's disease published by Alzheimer's Disease International in 2015, there will be 9.9 million new patients worldwide with Alzheimer's disease in 2015, with a new Alzheimer's patient diagnosed, on average, every 3 seconds. Since Alzheimer's disease is an irreversible disease, the most that can be done for Alzheimer's patients is to merely delay the onset of disease, which to date cannot be completely cured. Therefore, even tho...
A new drainage tube device

Chao He, Ming Zhao, Dong Yang, Tianya Wu, Leiyu Qiu

2016, 2(1): 71-73.   doi:10.18679/CN11-6030/R.2016.004
Abstract ( 475 )    PDF(3168KB) ( 442 ) HTML ()   Save
Objective: Drainage tubes (e.g., intracranial, abdominal cavity and thoracic) are commonly used to drain blood and fluid collections after surgery. It usually fails due to the lack of fixation perpendicular to the skin and the variety of tube materials. The objective of the article is to describe a new drainage tube device. Methods: This new device consists of a drainage tube fixator and diverter with a rotating handle. The fixator and diverter are fixed to the ...
Special section on early laboratory diagnosis of neurological diseases

Submission guidelines

2016, 2(1): 74-74.  
Abstract ( 198 )    PDF(148KB) ( 267 ) HTML ()   Save
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