Translational Neuroscience and Clinics

Are life sciences all about life?

Dajue Wang

2016, 2(2): 75-76. doi:10.18679/CN11-6030/R.2016.020

Abstract ( 415 )

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Brain function is an extremely active dynamic process. Studing a living organism is essential for explaination of the sophistication of the brain. Although there are progresses in studying living tissues of acute or cultured slice for prolonged period in vitro, clinicians prefer seeing the lesion directly on an imaging screen or material. Functional MRI (fMRI) is commonly used method to study brain pathology in dynamics.

Preliminary analysis of cellular sociology of co-cultured glioma initiating cells and macrophages in vitro

Mingxia Zhang, Junjie Chen, Lin Wang, Xiaoyan Ji, Lin Yang, Yujing Sheng, Hairui Liu, Haiyang Wang, Aidong Wang, Xingliang Dai, Xiaonan Li, Qiang Huang, Jun Dong

2016, 2(2): 77-86. doi:10.18679/CN11-6030/R.2016.018

Abstract ( 663 )

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Objective: Real-time monitoring of cytokine secretion at the single immunocyte level, based on the concept of immune cells, sociology has been recently reported. However, the relationships between glioma-initiating cells (GICs) and host immune cells and their mutual interactions in the tumor microenvironment have not been directly observed and remain unclear.
Methods: The dual fluorescence tracing technique was applied to label the co-cultured GICs and host...

Behavioral features of mice fed with a cholesterol-enriched diet:Deficient novelty exploration and unaltered aggressive behavior

Ekaterina Veniaminova, Raymond Cespuglio, Nataliia Markova, Niall Mortimer, Chi Wai Cheung, Harry W. Steinbusch, Klaus-Peter Lesch, Tatyana Strekalova

2016, 2(2): 87-95. doi:10.18679/CN11-6030/R.2016.014

Abstract ( 335 )

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Objectives: Previous studies involving mice have demonstrated that a cholesterol-enriched diet evokes liver steatosis, dystrophy, inflammation, and aspects of non-alcoholic fatty liver disease (NAFLD). These changes are accompanied by the activation of pro-inflammatory brain and liver molecular pathways, as well as anxiety and depressive-like behaviors. Given previously reported evidence for the neurobiological relationship between the above-mentioned molecular changes and abnor...

A study of the effects of 3,5-diiodo-L-thyronine in the tail suspension and forced swim models of depression

Nataliia Markova, Anton Chernopiatko, Aslan Kubatiev, Sergey Bachurin, Harry M. W. Steinbusch, Tatyana Strekalova

2016, 2(2): 96-107. doi:10.18679/CN11-6030/R.2016.013

Abstract ( 592 )

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Objectives: Recent findings have further highlighted the role of the thyroid system in the pathophysiology of depression and revealed new physiologically relevant elements of the thyroid system. Our previous study showed an antidepressant-like effect of 3,5-diiodo-L-thyronine (T2), which was previously considered to be a physiologically inactive molecule, in mice. Here, we aimed to investigate the antidepressant-like effects of T2 further.
Methods: We studi...

Transplantation of neural progenitor cells differentiated from adipose tissue-derived stem cells for treatment of sciatic nerve injury

Shasha Dong Na Liu Yang Hu, Ping Zhang, Chao Pan, Youping Zhang, Yingxin Tang, Zhouping Tang

2016, 2(2): 108-119. doi:10.18679/CN11-6030/R.2016.016

Abstract ( 485 )

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Objectives: Currently, the clinical repair of sciatic nerve injury remains difficult. Previous studies have confirmed that transplantation of adipose tissue-derived stem cells promotes nerve regeneration and restoration at peripheral nerve injury sites.
Methods: In this study, adipose tissue-derived stem cells were induced to differentiate into neural progenitor cells, transfected with a green fluorescent protein-containing lentivirus, and then transplanted...

New frontiers in biomaterials research for tissue repair and regeneration

Huiling Liu, Haoran Liu, Aaron Clasky, Huilin Yang, Lei Yang

2016, 2(2): 120-137. doi:10.18679/CN11-6030/R.2016.017

Abstract ( 687 )

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The field of biomaterials has recently emerged to augment or replace lost or damaged tissues and organs due to the human body's limited ability to self-heal large defects. Historically, metallic components, polymers, ceramics, and composite materials were utilized as synthetic materials along with natural materials to assist in therapy. Various novel biomaterials were developed to respond to a significant amount of new medical challenges in the past decade. Therefore, there is a need to review t...

Antiparkinsonian treatment for depression in Parkinson's disease: Are selective serotonin reuptake inhibitors recommended?

Philippe De Deurwaerdère, Yuqiang Ding

2016, 2(2): 138-149. doi:10.18679/CN11-6030/R.2016.019

Abstract ( 445 )

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Depression is a frequent comorbid syndrome in Parkinson's disease. It is a difficult symptom to manage, as patients continuously receive antiparkinsonian medication and may also have to be treated for the amelioration of the side-effects of antiparkinsonian therapy. The first-line treatment for depression in Parkinson's disease is the use of selective serotonin reuptake inhibitors (SSRIs). The clinical efficacy of these medications in patients with Parkinson's disease is questionable. In fact, b...

A newly developed open-end intracranial hematoma drainage tube

Chao He, Nongnaphat Wanussakul, Dong Yang, Tianya Wu, Ming Zhao

2016, 2(2): 150-152. doi:10.18679/CN11-6030/R.2016.015

Abstract ( 520 )

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Objective: To design a new open-end intracranial hematoma drainage tube for clinical application.
Methods: The newly developed device consists of two parts:the plunger and barrel. On one side, the barrel is bullet shaped with an opening tip. The plunger is located in the middle cavity of the tube barrel and extended out at the open-end. It was designed for strengthening the tube barrel and for convenience in performing the drainage procedure. It can be used...

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