In 2024 systematic innovation of publishing was the key word in the book publishing industry. Facing the urgent challenges of survival, development, and value dilemmas in book publishing industry, systematic innovation of publishing conformed to the regularity of disruptive innovation, integrated development, and systematic reform. By adopting innovations in publishing content system, operational system, technological system and knowledge system, systematic innovation serves as an important pathway to promote the transformation and upgrading of publishing and to facilitate the high-quality development of publishing with the aim of forging ahead on the journey of building a strong publishing nation. This paper analyzes the urgency, regularity, and practicality of systematic innovation of publishing, offering both a retrospective review of the book publishing in 2024 and a guidance for the future of publishing. The urgency reflects the realistic foundation of systematic innovation of publishing, the regularity embodies the theories and logics of the systematic innovation, and the practicality underscores the construction paths for the systematic innovation. The publishing industry has entered a phase of stock competition, with continuous negative growth within the book market, shrinking overall market size, and sharply increasing survival pressures. The industry is facing three major developmental dilemmas: the loss of clear publishing methodology, the confusion regarding the logical structure of book market, and the bewilderment of publishing technology application. Consequently, publishers struggle with decisions on book production and sales strategies, thus creating uncertainty regarding effective transformation and upgrading in the publishing industry. This series of problems has plunged the publishing industry into a state of urgency. Facing the dilemmas, systematic innovation of publishing adheres to the regularity of integrating culture and technology, leveraging new publishing technologies to empower the innovation, and generating new quality productive forces of publishing by disruptive innovation. Subsequently, it takes the new quality productive forces of publishing as the new growth engines for integrated development of publishing, creating new forms, business models and ecosystems of publishing by deep integration of publishing. Meanwhile, it is required to adapt to the new quality productive forces of publishing. The alignment of publishing relations of production and the new quality productive forces of publishing should be attained by innovating publishing systems and mechanisms with systematic reform in publishing. Finally, high-quality development in publishing can be achieved by releasing new quality productive forces of publishing through the relations of production. Systematic innovation of publishing integrates a "four-in-one" construction framework, including the content system, operational system, technological system, and knowledge system of publishing. The innovation of the first three publishing systems catalyze the emergence of new publishing chains, platforms, and operational structures, serving as the source of an independent and complete publishing knowledge system. Moreover, the knowledge system of publishing ensures the sustainability and advancement of innovations in publishing chains, platforms, and systems. Systematic innovation of publishing is an inevitable pathway for the industry transformation and upgrading under the condition of new technologies. The publishing industry, supported by the "four-in-one" construction, can overcome barriers during transformation and develop through continuous innovation. For the high-quality development of publishing and the construction of a strong publishing nation, the work accomplished in each year represents solid accumulation and progressive strides forward.