International publishing groups, such as Cell Press, have introduced a “Multiple-Journal Submission” model based on journal clusters in recent years. This model allows authors to submit their manuscripts to multiple journals simultaneously, thus enhancing the efficiency of manuscript processing through collaborative review across multiple journals. This model poses new requirements for editors. To advance journal clustering under the “Multiple-Journal Submission” model, this paper analyzes the characteristics of “Multiple-Journal Submission” model proposed by international publishing groups, investigates the evolving responsibilities and core capabilities required for editors, and further explores pathways for editorial talents cultivation. The "Multi-Journal Submission" model of Cell Press has shifted the publishing model from individual journal to integrated journal clusters. This innovative practice represents international publishing groups’ efforts to integrate publishing resources across multidisciplinary journals and to provide clustered services. This model offers valuable insights for the construction and development of journal clusters in China. By integrating the publishing resources within journal clusters, it significantly improves manuscript processing efficiency, reduces submission time to multiple journals, facilitates high-quality manuscript publication within the clusters, prevents the loss of excellent manuscripts, and enhances the overall competitiveness of the journal clusters. The operation of the "Multi-Journal Submission" model relies on a professional, diverse, and collaborative editorial team. The composition of the "Multi-Journal Submission" editorial team differs significantly from that of the traditional individual-journal submission. Under the "Multi-Journal Submission" model, the manuscripts are processed by both editors of the target journals and the handling editors from the “Multi-Journal Submission” system. The handling editors participate in the complete process of the review and management of the manuscripts. Besides serving as gatekeepers for the journals, the editors in the "Multi-Journal Submission" system are expected to enhance their ability to identify the academic value of manuscripts, strengthen leadership in knowledge services, improve interdisciplinary writing skills, and maintain continuous learning capabilities to adapt to this innovative publishing model. The "Multi-Journal Submission" service features multi-journal collaboration, multi-disciplinary evaluation, and cross-journal integration. The editorial team needs to possess the professional qualities of traditional editors and to adapt to cross-journal collaborative work. The responsibilities of the editors shift from serving individual journals to coordinating multiple journal cooperation, and the editors possess a wide range of skills, including cross-journal communication, multidisciplinary evaluation, and resource integration and utilization. As journal clustering continues to advance, the training system of editorial talents urgently needs to be innovated to accommodate the "Multi-Journal Submission" model. Consequently, the academic publishing industry must reassess the requirements for editors and adjust the focus of editor training accordingly. Chinese journal clusters should implement further measures to enhance journal cooperation, optimize the cluster management, and cultivate high-quality editorial talents for cluster-based services. The cultivating pathways of editorial talents include advanced training or education to enhance research capabilities, precisely targeted recruitment of multidisciplinary talents, and cultivation of versatile, communication-oriented editors. These efforts are essential to providing the high-quality editorial talents needed in the development of Chinese journal clusters.